Wilkes-Barre
- County:
- Luzerne County
- County Seat:
- Yes
- Area (mi²):
- 6.848
- State:
- Pennsylvania
Wilkes-Barre is a city located in Luzerne County, Pennsylvania. Wilkes-Barre has a 2026 population of 44,661. It is also the county seat of Luzerne County. Wilkes-Barre is currently growing at a rate of 0.53% annually and its population has increased by 0.87% since the most recent census, which recorded a population of 44,277 in 2020.