Tlaxcala's 2020 population is now estimated at 596,362. In 1950, the population of Tlaxcala was 29,227. Tlaxcala has grown by 50,014 since 2015, which represents a 1.77% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects. These estimates represent the Urban agglomeration of Tlaxcala, which typically includes Tlaxcala's population in addition to adjacent suburban areas.