| Airport | City | ICAO | Enplanements (2019) |
|---|---|---|---|
| St. Louis Lambert International Airport | St. Louis | KSTL | 7,631,953 |
| Kansas City International Airport (originally Mid-Continent International Airport) | Kansas City | KMCI | 5,790,847 |
| Springfield–Branson National Airport | Springfield | KSGF | 523,108 |
| Columbia Regional Airport | Columbia | KCOU | 120,235 |
| Joplin Regional Airport | Joplin | KJLN | 40,013 |