10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pueblo | 1 | 110,980 | 111,910 | -0.17% | 1,965 | 56 | City |
| Pueblo West | 2 | 35,512 | 32,842 | 1.12% | 716 | 50 | CDP |
| Colorado City | 3 | 1,867 | 2,200 | -1.11% | 124 | 15 | CDP |
| Salt Creek | 4 | 841 | 726 | 2.06% | 1,947 | 0 | CDP |
| Beulah Valley | 5 | 665 | 505 | 1.06% | 259 | 3 | CDP |
| Blende | 6 | 609 | 802 | -2.87% | 726 | 1 | CDP |
| Vineland | 7 | 442 | 339 | 2.79% | 781 | 1 | CDP |
| Boone | 8 | 308 | 305 | 0% | 813 | 0 | Town |
| Avondale | 9 | 305 | 588 | -7.58% | 486 | 1 | CDP |
| Rye | 10 | 202 | 207 | -0.49% | 2,149 | 0 | Town |
Pueblo is the largest city in Pueblo County, with a population of 110,980.
Rye is the smallest city in Pueblo County, with a population of 202.
There are 10 cities in Pueblo County, Colorado.