4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Green Cove Springs | 1 | 10,141 | 9,868 | 0.54% | 1,205 | 8 | City |
| Orange Park | 2 | 8,969 | 9,089 | -0.27% | 2,465 | 4 | Town |
| Keystone Heights | 3 | 1,596 | 1,446 | 1.92% | 1,485 | 1 | City |
| Penney Farms | 4 | 837 | 825 | 0.24% | 574 | 1 | Town |
Green Cove Springs is the largest city in Clay County, with a population of 10,141.
Penney Farms is the smallest city in Clay County, with a population of 837.
There are 4 cities in Clay County, Florida.