22 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jeffersonville | 1 | 63,933 | 61,542 | 0.85% | 2,405 | 27 | Township |
| Jeffersonville | 2 | 52,347 | 49,566 | 1.07% | 1,536 | 34 | City |
| Clarksville | 3 | 22,134 | 22,319 | -0.17% | 2,205 | 10 | Town |
| Charlestown | 4 | 16,296 | 15,216 | 0.75% | 252 | 65 | Township |
| Silver Creek | 5 | 14,630 | 13,823 | 0.61% | 878 | 17 | Township |
| Sellersburg | 6 | 10,514 | 9,374 | 2.22% | 1,419 | 7 | Town |
| Utica | 7 | 9,391 | 8,201 | 3.16% | 436 | 22 | Township |
| Charlestown | 8 | 8,886 | 7,821 | 2.46% | 776 | 11 | City |
| Carr | 9 | 5,123 | 4,853 | 0.67% | 194 | 26 | Township |
| Union | 10 | 4,768 | 4,553 | 0.89% | 229 | 21 | Township |
| Wood | 11 | 2,896 | 2,772 | 0.87% | 74 | 39 | Township |
| Oregon | 12 | 1,846 | 1,741 | 1.21% | 59 | 31 | Township |
| Henryville | 13 | 1,820 | 1,698 | -0.33% | 644 | 3 | CDP |
| Utica | 14 | 1,479 | 871 | 8.99% | 1,242 | 1 | Town |
| Galena | 15 | 1,453 | 1,253 | -1.62% | 544 | 3 | CDP |
| New Pekin | 16 | 1,321 | 1,325 | -0.08% | 554 | 2 | Town |
| Owen | 17 | 1,004 | 946 | 1.21% | 59 | 17 | Township |
| Memphis | 18 | 909 | 866 | 1.68% | 350 | 3 | CDP |
| Borden | 19 | 819 | 783 | 0.86% | 588 | 1 | Town |
| Bethlehem | 20 | 730 | 728 | 0.27% | 21 | 35 | Township |
| New Washington | 21 | 437 | 571 | -2.02% | 84 | 5 | CDP |
| Bethlehem | 22 | 380 | 366 | 0.8% | 21 | 18 | Township |
Jeffersonville is the largest city in Clark County, with a population of 63,933.
Bethlehem is the smallest city in Clark County, with a population of 380.
There are 22 cities in Clark County, Indiana.