12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jeffersonville | 1 | 52,347 | 49,566 | 1.07% | 1,536 | 34.08 | City |
| Clarksville | 2 | 22,134 | 22,319 | -0.17% | 2,205 | 10.04 | Town |
| Sellersburg | 3 | 10,514 | 9,374 | 2.22% | 1,419 | 7.41 | Town |
| Charlestown | 4 | 8,886 | 7,821 | 2.46% | 776 | 11.45 | City |
| Henryville | 5 | 1,820 | 1,698 | -0.33% | 644 | 2.83 | CDP |
| Utica | 6 | 1,479 | 871 | 8.99% | 1,242 | 1.19 | Town |
| Galena | 7 | 1,453 | 1,253 | -1.63% | 544 | 2.67 | CDP |
| New Pekin | 8 | 1,321 | 1,325 | -0.08% | 554 | 2.38 | Town |
| Memphis | 9 | 909 | 866 | 1.68% | 350 | 2.60 | CDP |
| Borden | 10 | 819 | 783 | 0.86% | 588 | 1.39 | Town |
| New Washington | 11 | 437 | 571 | -2.02% | 84 | 5.21 | CDP |
| Otisco | 12 | 139 | 0 | 6.92% | 348 | 0.40 | CDP |
Jeffersonville is the largest city in Clark County, with a population of 52,347.
Otisco is the smallest city in Clark County.
There are 12 cities in Clark County, Indiana.