10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Madisonville | 1 | 19,233 | 19,538 | -0.32% | 1,076 | 17.87 | City |
| Dawson Springs | 2 | 2,050 | 2,452 | -3.76% | 534 | 3.84 | City |
| Earlington | 3 | 1,242 | 1,259 | -0.24% | 440 | 2.82 | City |
| Nortonville | 4 | 977 | 976 | 0% | 843 | 1.16 | City |
| White Plains | 5 | 841 | 828 | 0.36% | 259 | 3.25 | City |
| Hanson | 6 | 746 | 750 | -0.13% | 317 | 2.35 | City |
| Mortons Gap | 7 | 724 | 721 | 0.14% | 611 | 1.18 | City |
| St. Charles | 8 | 285 | 272 | 1.06% | 287 | 0.99 | City |
| Nebo | 9 | 203 | 207 | -0.49% | 819 | 0.25 | City |
| Manitou | 10 | 183 | 530 | 0% | 278 | 0.66 | CDP |
Madisonville is the largest city in Hopkins County, with a population of 19,233.
Manitou is the smallest city in Hopkins County.
There are 10 cities in Hopkins County, Kentucky.