Kirksville is a city located in Adair County Missouri. It is also the county seat of Adair County. With a 2020 population of 17,496, it is the 43rd largest city in Missouri and the 2067th largest city in the United States . Kirksville is currently declining at a rate of -0.30% annually and its population has decreased by -0.05% since the most recent census, which recorded a population of 17,505 in 2010. Kirksville reached it's highest population of in . Spanning over 14 miles, Kirksville has a population density of 1,216 people per square mile.
The average household income in Kirksville is $49,191 with a poverty rate of 30.85%. The median rental costs in recent years comes to $643 per month, and the median house value is $118,400. The median age in Kirksville is 23.6 years, 23.5 years for males, and 23.7 years for females.