27 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Amherst Town | 1 | 44,284 | 27,806 | 8.04% | 1,603 | 28 | City |
| Greenfield | 2 | 17,613 | 17,712 | -0.11% | 823 | 21 | City |
| Montague | 3 | 8,430 | 8,568 | -0.08% | 280 | 30 | Town |
| Orange | 4 | 7,594 | 7,566 | 0.15% | 217 | 35 | Town |
| Deerfield | 5 | 5,176 | 5,093 | -0.02% | 160 | 32 | Town |
| Sunderland | 6 | 3,620 | 3,655 | -0.22% | 255 | 14 | Town |
| Northfield | 7 | 2,893 | 2,865 | 0.45% | 84 | 34 | Town |
| Bernardston | 8 | 2,107 | 2,097 | -0.09% | 90 | 23 | Town |
| Shelburne | 9 | 1,870 | 1,884 | -0.21% | 81 | 23 | Town |
| Leverett | 10 | 1,861 | 1,861 | -0.11% | 82 | 23 | Town |
| Buckland | 11 | 1,829 | 1,811 | 0.61% | 93 | 20 | Town |
| Conway | 12 | 1,748 | 1,765 | -0.34% | 46 | 38 | Town |
| Shutesbury | 13 | 1,713 | 1,720 | -0.23% | 65 | 27 | Town |
| Ashfield | 14 | 1,681 | 1,686 | -0.24% | 42 | 40 | Town |
| Colrain | 15 | 1,658 | 1,605 | 0.91% | 38 | 43 | Town |
| Erving | 16 | 1,658 | 1,659 | -0.18% | 120 | 14 | Town |
| Whately | 17 | 1,625 | 1,618 | -0.06% | 81 | 20 | Town |
| Gill | 18 | 1,555 | 1,547 | 0.13% | 113 | 14 | Town |
| Charlemont | 19 | 1,178 | 1,186 | -0.08% | 45 | 26 | Town |
| New Salem | 20 | 1,032 | 982 | 0.88% | 23 | 45 | Town |
| Wendell | 21 | 912 | 927 | -0.44% | 29 | 32 | Town |
| Warwick | 22 | 772 | 782 | -0.26% | 21 | 37 | Town |
| Leyden | 23 | 738 | 734 | 0.41% | 41 | 18 | Town |
| Heath | 24 | 715 | 721 | -0.28% | 29 | 25 | Town |
| Rowe | 25 | 418 | 422 | -0.24% | 18 | 23 | Town |
| Hawley | 26 | 352 | 352 | 0% | 12 | 30 | Town |
| Monroe | 27 | 115 | 116 | 0% | 11 | 11 | Town |
Amherst Town is the largest city in Franklin County, with a population of 44,284.
Monroe is the smallest city in Franklin County, with a population of 115.
There are 27 cities in Franklin County, Massachusetts.