5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Columbus | 1 | 22,395 | 23,995 | -1.41% | 894 | 25 | City |
| New Hope | 2 | 2,930 | 3,829 | -0.61% | 582 | 5 | CDP |
| Columbus AFB | 3 | 1,442 | 1,689 | 0.35% | 942 | 2 | CDP |
| Crawford | 4 | 410 | 415 | -0.24% | 293 | 1 | Town |
| Artesia | 5 | 316 | 325 | -0.63% | 337 | 1 | Town |
Columbus is the largest city in Lowndes County, with a population of 22,395.
Artesia is the smallest city in Lowndes County, with a population of 316.
There are 5 cities in Lowndes County, Mississippi.