5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Poplar Bluff | 1 | 16,084 | 16,204 | -0.15% | 1,224 | 13.14 | City |
| Qulin | 2 | 468 | 467 | 0% | 1,038 | 0.45 | City |
| Neelyville | 3 | 311 | 318 | -0.32% | 270 | 1.15 | City |
| Fisk | 4 | 309 | 313 | -0.32% | 954 | 0.32 | City |
| Broseley | 5 | 69 | 168 | 7.81% | 133 | 0.52 | CDP |
Poplar Bluff is the largest city in Butler County, with a population of 16,084.
Broseley is the smallest city in Butler County.
There are 5 cities in Butler County, Missouri.