9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bowling Green | 1 | 4,565 | 4,004 | 2.52% | 1,698 | 3 | City |
| Louisiana | 2 | 3,276 | 3,206 | 0.43% | 1,045 | 3 | City |
| Eolia | 3 | 490 | 475 | 0.62% | 402 | 1 | Village |
| Clarksville | 4 | 378 | 372 | 0.27% | 651 | 1 | City |
| Frankford | 5 | 353 | 343 | 0.57% | 806 | 0 | City |
| Curryville | 6 | 206 | 198 | 0.98% | 752 | 0 | City |
| Bowling Green | 7 | 92 | 92 | 0% | 2 | 39 | Township |
| Paynesville | 8 | 61 | 60 | 0% | 232 | 0 | Village |
| Annada | 9 | 12 | 12 | 0% | 197 | 0 | Village |
Bowling Green is the largest city in Pike County, with a population of 4,565.
Annada is the smallest city in Pike County, with a population of 12.
There are 9 cities in Pike County, Missouri.