28 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Las Cruces | 1 | 117,021 | 111,698 | 0.92% | 1,521 | 77 | City |
| Sunland Park | 2 | 18,283 | 16,798 | 1.65% | 1,241 | 15 | City |
| Chaparral | 3 | 15,455 | 13,744 | 0.36% | 262 | 59 | CDP |
| Anthony | 4 | 8,739 | 8,706 | 0.08% | 3,238 | 3 | City |
| Santa Teresa | 5 | 6,931 | 6,553 | 2.65% | 783 | 9 | CDP |
| Vado | 6 | 3,434 | 3,189 | 0.47% | 1,153 | 3 | CDP |
| Westway | 7 | 3,303 | 3,365 | -1.75% | 2,875 | 1 | CDP |
| University Park | 8 | 2,382 | 2,917 | -4.83% | 1,552 | 2 | CDP |
| Picacho Hills | 9 | 2,278 | 1,770 | 7.15% | 703 | 3 | CDP |
| Mesilla | 10 | 1,786 | 1,801 | -0.17% | 314 | 6 | Town |
| Radium Springs | 11 | 1,646 | 1,487 | -0.24% | 276 | 6 | CDP |
| Hatch | 12 | 1,581 | 1,548 | 0.44% | 526 | 3 | Village |
| White Sands | 13 | 1,399 | 1,368 | -1.13% | 331 | 4 | CDP |
| Doña Ana | 14 | 1,377 | 1,375 | 0.81% | 2,155 | 1 | CDP |
| Berino | 15 | 1,202 | 1,704 | -1.31% | 1,279 | 1 | CDP |
| Fairacres | 16 | 965 | 1,213 | 0.94% | 458 | 2 | CDP |
| Tortugas | 17 | 885 | 762 | 7.14% | 4,447 | 0 | CDP |
| Salem | 18 | 820 | 586 | -0.97% | 627 | 1 | CDP |
| La Union | 19 | 810 | 907 | -2.41% | 196 | 4 | CDP |
| Butterfield Park | 20 | 745 | 513 | 7.19% | 1,656 | 0 | CDP |
| Chamberino | 21 | 670 | 687 | -2.47% | 219 | 3 | CDP |
| La Mesa | 22 | 630 | 642 | -1.1% | 265 | 2 | CDP |
| Mesquite | 23 | 468 | 892 | -8.41% | 571 | 1 | CDP |
| San Miguel | 24 | 454 | 1,006 | -9.38% | 198 | 2 | CDP |
| Rodey | 25 | 391 | 648 | 0.26% | 699 | 1 | CDP |
| San Pablo | 26 | 360 | 1,022 | -7.69% | 296 | 1 | CDP |
| Rincon | 27 | 266 | 494 | 0% | 252 | 1 | CDP |
| Organ | 28 | 42 | 192 | -30% | 49 | 1 | CDP |
Las Cruces is the largest city in Doña Ana County, with a population of 117,021.
Organ is the smallest city in Doña Ana County, with a population of 42.
There are 28 cities in Doña Ana County, New Mexico.