19 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pee Pee | 1 | 7,289 | 7,377 | -0.21% | 231 | 31 | Township |
| Beaver | 2 | 6,668 | 6,743 | -0.1% | 198 | 34 | Township |
| Waverly | 3 | 4,085 | 4,157 | -0.34% | 981 | 4 | Village |
| Seal | 4 | 3,378 | 3,347 | 0.06% | 119 | 28 | Township |
| Pebble | 5 | 2,449 | 2,458 | 0% | 67 | 37 | Township |
| Piketon | 6 | 2,175 | 2,130 | 0.42% | 865 | 3 | Village |
| Newton | 7 | 1,793 | 1,798 | -0.06% | 59 | 30 | Township |
| Benton | 8 | 1,578 | 1,594 | -0.19% | 41 | 39 | Township |
| Beaver | 9 | 1,260 | 1,263 | 0% | 53 | 24 | Township |
| Union | 10 | 1,256 | 1,261 | -0.08% | 53 | 24 | Township |
| Mifflin | 11 | 1,201 | 1,188 | 0.33% | 26 | 46 | Township |
| Sunfish | 12 | 1,158 | 1,153 | 0.17% | 35 | 33 | Township |
| Scioto | 13 | 1,032 | 1,042 | -0.19% | 42 | 24 | Township |
| Camp Creek | 14 | 1,008 | 1,009 | 0% | 37 | 27 | Township |
| Beaver | 15 | 760 | 755 | 0.26% | 26 | 29 | Township |
| Jasper | 16 | 689 | 690 | 0.15% | 17 | 41 | Township |
| Clarktown | 17 | 590 | 477 | -4.07% | 289 | 2 | CDP |
| Beaver | 18 | 432 | 441 | -0.46% | 1,108 | 0 | Village |
| Cynthiana | 19 | 29 | 29 | 7.41% | 853 | 0 | CDP |
Pee Pee is the largest city in Pike County, with a population of 7,289.
Cynthiana is the smallest city in Pike County, with a population of 29.
There are 19 cities in Pike County, Ohio.