13 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Holdenville | 1 | 5,916 | 5,920 | -0.02% | 1,178 | 5.02 | City |
| Wetumka | 2 | 1,138 | 1,130 | 0.18% | 604 | 1.88 | City |
| Dustin | 3 | 330 | 320 | 0.61% | 510 | 0.65 | Town |
| Calvin | 4 | 315 | 312 | 0.32% | 350 | 0.90 | Town |
| Dixon | 5 | 210 | 223 | 7.14% | 360 | 0.58 | CDP |
| Stuart | 6 | 194 | 194 | 0% | 711 | 0.27 | Town |
| Spaulding | 7 | 152 | 147 | 0.66% | 48 | 3.15 | Town |
| Lamar | 8 | 124 | 118 | 0.81% | 10 | 11.99 | Town |
| Horntown | 9 | 96 | 91 | 1.05% | 24 | 3.95 | Town |
| Atwood | 10 | 87 | 84 | 1.16% | 289 | 0.30 | Town |
| Lima | 11 | 65 | 67 | 0% | 138 | 0.47 | Town |
| Yeager | 12 | 51 | 46 | 2% | 273 | 0.19 | Town |
| Ashland | 13 | 30 | 32 | 0% | 151 | 0.20 | Town |
Holdenville is the largest city in Hughes County, with a population of 5,916.
Ashland is the smallest city in Hughes County.
There are 13 cities in Hughes County, Oklahoma.