7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Stillwater | 1 | 50,282 | 48,389 | 0.76% | 1,688 | 29.79 | City |
| Cushing | 2 | 8,441 | 8,316 | 0.3% | 1,111 | 7.59 | City |
| Perkins | 3 | 3,305 | 3,217 | 0.55% | 1,132 | 2.92 | City |
| Yale | 4 | 1,074 | 1,061 | 0.28% | 1,172 | 0.92 | City |
| Glencoe | 5 | 516 | 500 | 0.58% | 308 | 1.67 | Town |
| Ripley | 6 | 354 | 346 | 0.57% | 747 | 0.47 | Town |
| Mehan | 7 | 85 | 75 | 7.6% | 607 | 0.14 | CDP |
Stillwater is the largest city in Payne County, with a population of 50,282.
Mehan is the smallest city in Payne County.
There are 7 cities in Payne County, Oklahoma.