22 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Sallisaw | 1 | 8,751 | 8,548 | 0.49% | 631 | 14 | City |
| Sallisaw | 2 | 8,751 | 8,533 | 0.49% | 631 | 14 | City |
| Roland | 3 | 4,178 | 3,365 | 3.9% | 1,394 | 3 | Town |
| Roland | 4 | 4,178 | 3,390 | 3.9% | 1,394 | 3 | Town |
| Muldrow | 5 | 3,382 | 3,261 | 0.71% | 798 | 4 | Town |
| Muldrow | 6 | 3,382 | 3,260 | 0.71% | 798 | 4 | Town |
| Vian | 7 | 1,387 | 1,382 | 0.07% | 1,037 | 1 | Town |
| Vian | 8 | 1,387 | 1,379 | 0.07% | 1,037 | 1 | Town |
| Gore | 9 | 1,001 | 993 | 0.2% | 434 | 2 | Town |
| Gore | 10 | 1,001 | 991 | 0.2% | 434 | 2 | Town |
| Brushy | 11 | 991 | 1,000 | 0.61% | 38 | 26 | CDP |
| Brent | 12 | 687 | 698 | -0.29% | 61 | 11 | CDP |
| Akins | 13 | 500 | 881 | 0% | 37 | 14 | CDP |
| Gans | 14 | 253 | 248 | 0.4% | 1,166 | 0 | Town |
| Gans | 15 | 253 | 247 | 0.4% | 1,166 | 0 | Town |
| Hanson | 16 | 214 | 168 | 7% | 656 | 0 | CDP |
| Stoney Point | 17 | 202 | 210 | -0.98% | 9 | 23 | CDP |
| Marble City | 18 | 185 | 183 | 0% | 456 | 0 | Town |
| Marble City | 19 | 185 | 183 | 0% | 456 | 0 | Town |
| Badger Lee | 20 | 56 | 47 | 7.69% | 79 | 1 | CDP |
| Moffett | 21 | 32 | 32 | 0% | 33 | 1 | Town |
| Moffett | 22 | 32 | 32 | 0% | 33 | 1 | Town |
Sallisaw is the largest city in Sequoyah County, with a population of 8,751.
Moffett is the smallest city in Sequoyah County, with a population of 32.
There are 22 cities in Sequoyah County, Oklahoma.