23 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Anderson | 1 | 30,316 | 29,476 | 0.56% | 1,894 | 16.01 | City |
| Berea | 2 | 16,656 | 15,104 | 0.95% | 2,164 | 7.70 | CDP |
| Powdersville | 3 | 13,348 | 9,436 | 7.14% | 970 | 13.76 | CDP |
| Clemson University | 4 | 7,771 | 5,329 | 7.14% | 3,671 | 2.12 | CDP |
| Homeland Park | 5 | 7,740 | 6,570 | 1.26% | 1,644 | 4.71 | CDP |
| Centerville | 6 | 7,375 | 6,816 | 0.72% | 1,249 | 5.91 | CDP |
| Welcome | 7 | 7,274 | 7,743 | 0.55% | 1,577 | 4.61 | CDP |
| Belton | 8 | 4,623 | 4,343 | 1.23% | 1,210 | 3.82 | City |
| Williamston | 9 | 4,329 | 4,054 | 1.29% | 1,173 | 3.69 | Town |
| Northlake | 10 | 4,050 | 3,684 | 0.5% | 979 | 4.14 | CDP |
| Honea Path | 11 | 3,953 | 3,690 | 1.36% | 1,125 | 3.51 | Town |
| Pendleton | 12 | 3,762 | 3,499 | 1.43% | 767 | 4.91 | Town |
| Golden Grove | 13 | 3,486 | 3,449 | 1.99% | 604 | 5.78 | CDP |
| Pelzer | 14 | 1,441 | 1,345 | 1.34% | 1,577 | 0.91 | Town |
| La France | 15 | 1,239 | 856 | 7.18% | 956 | 1.30 | CDP |
| Cateechee | 16 | 1,216 | 738 | 7.14% | 2,380 | 0.51 | CDP |
| Iva | 17 | 1,203 | 1,130 | 1.26% | 1,175 | 1.02 | Town |
| Sandy Springs | 18 | 1,091 | 974 | 7.17% | 380 | 2.87 | CDP |
| West Pelzer | 19 | 1,034 | 964 | 1.37% | 1,718 | 0.60 | Town |
| Chickasaw Point | 20 | 754 | 532 | 7.1% | 345 | 2.19 | CDP |
| South Union | 21 | 479 | 332 | 7.16% | 184 | 2.60 | CDP |
| Starr | 22 | 177 | 164 | 1.72% | 118 | 1.50 | Town |
| Ware Place | 23 | 63 | 116 | -14.87% | 69 | 0.92 | CDP |
Anderson is the largest city in Anderson County, with a population of 30,316.
Ware Place is the smallest city in Anderson County.
There are 23 cities in Anderson County, South Carolina.