23 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Anderson | 1 | 31,306 | 29,458 | 1.19% | 1,956 | 16 | City |
| Berea | 2 | 16,656 | 15,104 | 0.95% | 2,164 | 8 | CDP |
| Powdersville | 3 | 13,348 | 9,436 | 7.14% | 970 | 14 | CDP |
| Clemson University | 4 | 7,771 | 5,329 | 7.14% | 3,671 | 2 | CDP |
| Homeland Park | 5 | 7,740 | 6,570 | 1.26% | 1,644 | 5 | CDP |
| Centerville | 6 | 7,375 | 6,816 | 0.72% | 1,249 | 6 | CDP |
| Welcome | 7 | 7,274 | 7,743 | 0.55% | 1,577 | 5 | CDP |
| Belton | 8 | 4,630 | 4,343 | 1.25% | 1,212 | 4 | City |
| Williamston | 9 | 4,342 | 4,056 | 1.33% | 1,177 | 4 | Town |
| Northlake | 10 | 4,050 | 3,684 | 0.5% | 979 | 4 | CDP |
| Honea Path | 11 | 3,933 | 3,693 | 1.24% | 1,119 | 4 | Town |
| Pendleton | 12 | 3,747 | 3,497 | 1.35% | 764 | 5 | Town |
| Golden Grove | 13 | 3,486 | 3,449 | 1.99% | 604 | 6 | CDP |
| Pelzer | 14 | 1,449 | 1,346 | 1.4% | 1,585 | 1 | Town |
| La France | 15 | 1,239 | 856 | 7.18% | 956 | 1 | CDP |
| Cateechee | 16 | 1,216 | 738 | 7.14% | 2,380 | 1 | CDP |
| Iva | 17 | 1,206 | 1,128 | 1.26% | 1,178 | 1 | Town |
| Sandy Springs | 18 | 1,091 | 974 | 7.17% | 380 | 3 | CDP |
| West Pelzer | 19 | 1,041 | 971 | 1.36% | 1,729 | 1 | Town |
| Chickasaw Point | 20 | 754 | 532 | 7.1% | 345 | 2 | CDP |
| South Union | 21 | 479 | 332 | 7.16% | 184 | 3 | CDP |
| Starr | 22 | 176 | 164 | 1.15% | 117 | 1 | Town |
| Ware Place | 23 | 63 | 116 | -14.86% | 69 | 1 | CDP |
Anderson is the largest city in Anderson County, with a population of 31,306.
Ware Place is the smallest city in Anderson County, with a population of 63.
There are 23 cities in Anderson County, South Carolina.