21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Greenville | 1 | 75,106 | 71,428 | 0.99% | 2,497 | 30 | City |
| Greer | 2 | 48,937 | 35,829 | 5.66% | 2,085 | 23 | City |
| Mauldin | 3 | 30,986 | 24,786 | 4.17% | 2,501 | 12 | City |
| Simpsonville | 4 | 29,196 | 23,605 | 3.98% | 3,084 | 9 | City |
| Taylors | 5 | 23,352 | 23,107 | 0.5% | 2,211 | 11 | CDP |
| Wade Hampton | 6 | 21,131 | 20,192 | 0.16% | 2,379 | 9 | CDP |
| Five Forks | 7 | 19,705 | 19,399 | 1.92% | 2,603 | 8 | CDP |
| Fountain Inn | 8 | 14,604 | 10,512 | 5.93% | 1,698 | 9 | City |
| Gantt | 9 | 14,288 | 14,556 | 0.03% | 1,460 | 10 | CDP |
| Parker | 10 | 12,725 | 12,175 | 0.69% | 1,861 | 7 | CDP |
| Travelers Rest | 11 | 9,245 | 7,819 | 3.18% | 1,481 | 6 | City |
| Sans Souci | 12 | 8,085 | 8,844 | 0.17% | 2,442 | 3 | CDP |
| Piedmont | 13 | 5,612 | 6,122 | 0.61% | 653 | 9 | CDP |
| Dunean | 14 | 3,366 | 3,099 | -0.59% | 2,147 | 2 | CDP |
| Tigerville | 15 | 2,324 | 2,023 | 2.97% | 1,749 | 1 | CDP |
| Slater-Marietta | 16 | 2,205 | 2,098 | 0.09% | 512 | 4 | CDP |
| Judson | 17 | 1,836 | 1,412 | -0.76% | 2,336 | 1 | CDP |
| City View | 18 | 1,784 | 1,607 | 1.71% | 4,598 | 0 | CDP |
| Conestee | 19 | 1,515 | 1,254 | 7.14% | 1,429 | 1 | CDP |
| The Cliffs Valley | 20 | 1,052 | 663 | 7.13% | 163 | 6 | CDP |
| Caesars Head | 21 | 52 | 53 | 6.12% | 35 | 1 | CDP |
Greenville is the largest city in Greenville County, with a population of 75,106.
Caesars Head is the smallest city in Greenville County, with a population of 52.
There are 21 cities in Greenville County, South Carolina.