9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Hampton | 1 | 2,547 | 2,704 | -1.2% | 564 | 4.51 | Town |
| Estill | 2 | 1,736 | 1,813 | -0.86% | 537 | 3.23 | Town |
| Varnville | 3 | 1,590 | 1,670 | -1% | 415 | 3.83 | Town |
| Yemassee | 4 | 1,073 | 1,095 | -0.37% | 98 | 10.90 | Town |
| Brunson | 5 | 408 | 428 | -0.97% | 401 | 1.02 | Town |
| Gifford | 6 | 246 | 258 | -0.81% | 254 | 0.97 | Town |
| Furman | 7 | 220 | 224 | -0.45% | 71 | 3.12 | Town |
| Scotia | 8 | 153 | 160 | -0.65% | 48 | 3.17 | Town |
| Luray | 9 | 93 | 97 | -1.06% | 90 | 1.03 | Town |
Hampton is the largest city in Hampton County, with a population of 2,547.
Luray is the smallest city in Hampton County.
There are 9 cities in Hampton County, South Carolina.