8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bishopville | 1 | 2,774 | 2,994 | -1.56% | 1,187 | 2.34 | City |
| Stateburg | 2 | 1,829 | 1,912 | 1.67% | 393 | 4.66 | CDP |
| Oakland | 3 | 889 | 1,265 | -2.52% | 1,307 | 0.68 | CDP |
| Elliott | 4 | 698 | 608 | 7.22% | 376 | 1.85 | CDP |
| East Sumter | 5 | 651 | 1,208 | -6.6% | 196 | 3.32 | CDP |
| Oswego | 6 | 440 | 197 | 7.06% | 365 | 1.21 | CDP |
| Lynchburg | 7 | 299 | 321 | -1.32% | 264 | 1.13 | Town |
| Shiloh | 8 | 190 | 210 | -1.04% | 19 | 9.76 | CDP |
Bishopville is the largest city in Lee County, with a population of 2,774.
Shiloh is the smallest city in Lee County.
There are 8 cities in Lee County, South Carolina.