18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Sherman | 1 | 49,813 | 43,963 | 2.4% | 1,072 | 46.45 | City |
| Denison | 2 | 27,543 | 24,542 | 2.23% | 949 | 29.02 | City |
| Van Alstyne | 3 | 8,323 | 4,470 | 10.21% | 1,496 | 5.56 | City |
| Whitesboro | 4 | 4,245 | 4,084 | 0.76% | 1,271 | 3.34 | City |
| Howe | 5 | 3,709 | 3,619 | 0.49% | 743 | 4.99 | Town |
| Pottsboro | 6 | 2,969 | 2,494 | 3.31% | 941 | 3.15 | Town |
| Gunter | 7 | 2,719 | 2,079 | 4.94% | 140 | 19.42 | City |
| Preston | 8 | 2,202 | 1,759 | 0.32% | 438 | 5.03 | CDP |
| Collinsville | 9 | 2,122 | 1,874 | 2.41% | 2,148 | 0.99 | Town |
| Whitewright | 10 | 1,808 | 1,728 | 0.89% | 987 | 1.83 | Town |
| Bells | 11 | 1,521 | 1,521 | 0% | 717 | 2.12 | Town |
| Tioga | 12 | 1,365 | 1,159 | 3.1% | 693 | 1.97 | Town |
| Southmayd | 13 | 1,142 | 994 | 2.7% | 405 | 2.82 | City |
| Tom Bean | 14 | 960 | 922 | 0.84% | 663 | 1.45 | City |
| Knollwood | 15 | 831 | 768 | 1.59% | 2,557 | 0.33 | City |
| Sherwood Shores | 16 | 802 | 658 | -3.14% | 282 | 2.85 | CDP |
| Sadler | 17 | 374 | 371 | 0.27% | 354 | 1.06 | City |
| Dorchester | 18 | 100 | 95 | 1.01% | 67 | 1.50 | City |
Sherman is the largest city in Grayson County, with a population of 49,813.
Dorchester is the smallest city in Grayson County.
There are 18 cities in Grayson County, Texas.