16 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Sherman | 1 | 53,364 | 43,959 | 3.03% | 1,149 | 46 | City |
| Denison | 2 | 27,398 | 24,542 | 1.77% | 944 | 29 | City |
| Van Alstyne | 3 | 8,598 | 4,464 | 8.71% | 1,545 | 6 | City |
| Whitesboro | 4 | 4,176 | 4,082 | 0.38% | 1,250 | 3 | City |
| Howe | 5 | 3,689 | 3,622 | 0.3% | 739 | 5 | Town |
| Pottsboro | 6 | 2,922 | 2,495 | 2.49% | 926 | 3 | Town |
| Gunter | 7 | 2,708 | 2,078 | 4.03% | 139 | 19 | City |
| Collinsville | 8 | 2,128 | 1,878 | 2.01% | 2,154 | 1 | Town |
| Whitewright | 9 | 1,775 | 1,733 | 0.4% | 969 | 2 | Town |
| Bells | 10 | 1,519 | 1,521 | 0% | 716 | 2 | Town |
| Tioga | 11 | 1,350 | 1,163 | 2.35% | 685 | 2 | Town |
| Southmayd | 12 | 1,142 | 994 | 2.24% | 405 | 3 | City |
| Tom Bean | 13 | 965 | 920 | 0.84% | 666 | 1 | City |
| Knollwood | 14 | 828 | 765 | 1.35% | 2,548 | 0 | City |
| Sadler | 15 | 363 | 371 | -0.27% | 343 | 1 | City |
| Dorchester | 16 | 105 | 95 | 1.94% | 70 | 1 | City |
Sherman is the largest city in Grayson County, with a population of 53,364.
Dorchester is the smallest city in Grayson County, with a population of 105.
There are 16 cities in Grayson County, Texas.