2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grape Creek | 1 | 4,700 | 3,851 | 2.24% | 300 | 16 | CDP |
| Mertzon | 2 | 764 | 751 | 0.26% | 503 | 2 | City |
Grape Creek is the largest city in Irion County, with a population of 4,700.
Mertzon is the smallest city in Irion County, with a population of 764.
There are 2 cities in Irion County, Texas.