2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grape Creek | 1 | 4,700 | 3,851 | 2.24% | 300 | 15.66 | CDP |
| Mertzon | 2 | 777 | 749 | 0.78% | 512 | 1.52 | City |
Grape Creek is the largest city in Irion County, with a population of 4,700.
Mertzon is the smallest city in Irion County.
There are 2 cities in Irion County, Texas.