4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Karnes City | 1 | 3,627 | 3,591 | 0.19% | 1,565 | 2 | City |
| Kenedy | 2 | 3,351 | 3,485 | -0.8% | 759 | 4 | City |
| Runge | 3 | 975 | 900 | 1.56% | 829 | 1 | Town |
| Falls City | 4 | 511 | 518 | -0.39% | 573 | 1 | City |
Karnes City is the largest city in Karnes County, with a population of 3,627.
Falls City is the smallest city in Karnes County, with a population of 511.
There are 4 cities in Karnes County, Texas.