4 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Karnes City | 1 | 3,634 | 3,591 | 0.19% | 1,568 | 2 | City |
| Kenedy | 2 | 3,324 | 3,485 | -0.81% | 753 | 4 | City |
| Runge | 3 | 990 | 900 | 1.54% | 842 | 1 | Town |
| Falls City | 4 | 510 | 518 | -0.2% | 572 | 1 | City |
Karnes City is the largest city in Karnes County, with a population of 3,634.
Falls City is the smallest city in Karnes County, with a population of 510.
There are 4 cities in Karnes County, Texas.