18 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Appleton | 1 | 75,281 | 75,593 | -0.08% | 2,972 | 25 | City |
| Fox Crossing | 2 | 19,454 | 18,992 | 0.48% | 1,539 | 13 | Village |
| Kaukauna | 3 | 18,671 | 17,131 | 1.68% | 2,331 | 8 | City |
| Greenville | 4 | 13,407 | 12,736 | 1.01% | 375 | 36 | Village |
| Little Chute | 5 | 11,766 | 11,739 | 0.04% | 1,822 | 6 | Village |
| Kimberly | 6 | 7,575 | 7,343 | 0.61% | 3,296 | 2 | Village |
| Seymour | 7 | 3,653 | 3,541 | 0.61% | 1,309 | 3 | City |
| Combined Locks | 8 | 3,607 | 3,636 | -0.17% | 2,101 | 2 | Village |
| Hortonville | 9 | 3,404 | 3,038 | 2.19% | 1,004 | 3 | Village |
| Seymour | 10 | 1,340 | 1,392 | -0.45% | 570 | 2 | CDP |
| Black Creek | 11 | 1,329 | 1,356 | -0.45% | 1,333 | 1 | Village |
| Shiocton | 12 | 929 | 941 | -0.32% | 594 | 2 | Village |
| Dale | 13 | 670 | 725 | 1.36% | 449 | 1 | CDP |
| Bear Creek | 14 | 416 | 428 | -0.72% | 451 | 1 | Village |
| Northport | 15 | 410 | 459 | -1.2% | 237 | 2 | CDP |
| Nichols | 16 | 284 | 287 | -0.35% | 321 | 1 | Village |
| Navarino | 17 | 133 | 154 | -2.21% | 119 | 1 | CDP |
| Tustin | 18 | 120 | 103 | 0.84% | 117 | 1 | CDP |
Appleton is the largest city in Outagamie County, with a population of 75,281.
Tustin is the smallest city in Outagamie County, with a population of 120.
There are 18 cities in Outagamie County, Wisconsin.