Grenoble's 2025 population is now estimated at 543,623. In 1950, the population of Grenoble was 156,273. Grenoble has grown by 3,371 in the last year, which represents a 0.62% annual change.These population estimates and projections come from the latest revision of the UN World Urbanization Prospects. These estimates represent the Urban agglomeration of Grenoble, which typically includes Grenoble's population in addition to adjacent suburban areas.