9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Forrest City | 1 | 12,165 | 12,977 | -1.31% | 601 | 20.25 | City |
| Hughes | 2 | 952 | 1,051 | -2.06% | 421 | 2.26 | City |
| Madison | 3 | 693 | 753 | -1.7% | 279 | 2.48 | City |
| Palestine | 4 | 464 | 504 | -1.69% | 136 | 3.40 | City |
| Caldwell | 5 | 415 | 450 | -1.66% | 130 | 3.19 | Town |
| Colt | 6 | 276 | 295 | -1.43% | 219 | 1.26 | City |
| Wheatley | 7 | 260 | 277 | -1.14% | 85 | 3.07 | City |
| Widener | 8 | 197 | 211 | -1.5% | 361 | 0.55 | Town |
| Goodwin | 9 | 151 | 181 | 7.09% | 33 | 4.52 | CDP |
Forrest City is the largest city in St. Francis County, with a population of 12,165.
Goodwin is the smallest city in St. Francis County.
There are 9 cities in St. Francis County, Arkansas.