5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Burlington | 1 | 23,471 | 23,968 | -0.35% | 1,629 | 14 | City |
| West Burlington | 2 | 3,274 | 3,198 | 0.4% | 677 | 5 | City |
| Mediapolis | 3 | 1,675 | 1,687 | -0.12% | 1,396 | 1 | City |
| Danville | 4 | 889 | 951 | -1.11% | 1,187 | 1 | City |
| Middletown | 5 | 366 | 363 | 0.27% | 667 | 1 | City |
Burlington is the largest city in Des Moines County, with a population of 23,471.
Middletown is the smallest city in Des Moines County, with a population of 366.
There are 5 cities in Des Moines County, Iowa.