5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jackson | 1 | 4,414 | 4,728 | -1.41% | 282 | 16 | City |
| Thomasville | 2 | 3,499 | 3,704 | -1.16% | 311 | 11 | City |
| Grove Hill | 3 | 1,700 | 1,812 | -1.33% | 224 | 8 | Town |
| Coffeeville | 4 | 245 | 259 | -1.21% | 54 | 5 | Town |
| Fulton | 5 | 210 | 223 | -1.41% | 86 | 2 | Town |
Jackson is the largest city in Clarke County, with a population of 4,414.
Fulton is the smallest city in Clarke County, with a population of 210.
There are 5 cities in Clarke County, Alabama.