13 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jackson | 1 | 4,414 | 4,751 | -1.41% | 282 | 16 | City |
| Jackson | 2 | 4,414 | 4,728 | -1.41% | 282 | 16 | City |
| Thomasville | 3 | 3,499 | 3,722 | -1.16% | 311 | 11 | City |
| Thomasville | 4 | 3,499 | 3,704 | -1.16% | 311 | 11 | City |
| Grove Hill | 5 | 1,700 | 1,821 | -1.33% | 224 | 8 | Town |
| Grove Hill | 6 | 1,700 | 1,812 | -1.33% | 224 | 8 | Town |
| Coffeeville | 7 | 245 | 260 | -1.21% | 54 | 5 | Town |
| Coffeeville | 8 | 245 | 259 | -1.21% | 54 | 5 | Town |
| Whatley | 9 | 231 | 279 | 2.21% | 179 | 1 | CDP |
| Fulton | 10 | 210 | 224 | -1.41% | 86 | 2 | Town |
| Fulton | 11 | 210 | 223 | -1.41% | 86 | 2 | Town |
| Carlton | 12 | 71 | 57 | 7.58% | 16 | 5 | CDP |
| Putnam | 13 | 28 | 54 | -28.21% | 3 | 9 | CDP |
Jackson is the largest city in Clarke County, with a population of 4,414.
Putnam is the smallest city in Clarke County, with a population of 28.
There are 13 cities in Clarke County, Alabama.