8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Florence | 1 | 43,248 | 40,586 | 1.25% | 1,627 | 27 | City |
| Underwood-Petersville | 2 | 3,035 | 2,707 | -0.46% | 524 | 6 | CDP |
| Rogersville | 3 | 1,445 | 1,287 | 2.19% | 476 | 3 | Town |
| Killen | 4 | 1,042 | 1,030 | 0.19% | 515 | 2 | Town |
| St. Florian | 5 | 741 | 620 | 3.35% | 166 | 4 | Town |
| Lexington | 6 | 739 | 728 | 0.27% | 228 | 3 | Town |
| Anderson | 7 | 258 | 253 | 0.39% | 200 | 1 | Town |
| Waterloo | 8 | 184 | 181 | 0% | 246 | 1 | Town |
Florence is the largest city in Lauderdale County, with a population of 43,248.
Waterloo is the smallest city in Lauderdale County, with a population of 184.
There are 8 cities in Lauderdale County, Alabama.