15 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Florence | 1 | 43,248 | 40,178 | 1.25% | 1,627 | 27 | City |
| Florence | 2 | 43,248 | 40,586 | 1.25% | 1,627 | 27 | City |
| Underwood-Petersville | 3 | 3,035 | 2,707 | -0.46% | 524 | 6 | CDP |
| Rogersville | 4 | 1,445 | 1,280 | 2.19% | 476 | 3 | Town |
| Rogersville | 5 | 1,445 | 1,287 | 2.19% | 476 | 3 | Town |
| Killen | 6 | 1,042 | 1,029 | 0.19% | 515 | 2 | Town |
| Killen | 7 | 1,042 | 1,030 | 0.19% | 515 | 2 | Town |
| St. Florian | 8 | 741 | 615 | 3.35% | 166 | 4 | Town |
| St. Florian | 9 | 741 | 620 | 3.35% | 166 | 4 | Town |
| Lexington | 10 | 739 | 728 | 0.27% | 228 | 3 | Town |
| Lexington | 11 | 739 | 728 | 0.27% | 228 | 3 | Town |
| Anderson | 12 | 258 | 253 | 0.39% | 200 | 1 | Town |
| Anderson | 13 | 258 | 253 | 0.39% | 200 | 1 | Town |
| Waterloo | 14 | 184 | 181 | 0% | 246 | 1 | Town |
| Waterloo | 15 | 184 | 181 | 0% | 246 | 1 | Town |
Florence is the largest city in Lauderdale County, with a population of 43,248.
Waterloo is the smallest city in Lauderdale County, with a population of 184.
There are 15 cities in Lauderdale County, Alabama.