| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Florence | 1 | 43,097 | 40,585 | 1.21% | 1,591 | 27 | City |
| Rogersville | 2 | 1,465 | 1,287 | 2.16% | 483 | 3 | Town |
| Killen | 3 | 1,041 | 1,026 | 0.19% | 514 | 2 | Town |
| St. Florian | 4 | 771 | 620 | 3.07% | 173 | 4 | Town |
| Lexington | 5 | 737 | 728 | 0.27% | 228 | 3 | Town |
| Anderson | 6 | 258 | 253 | 0.39% | 200 | 1 | Town |
| Waterloo | 7 | 183 | 181 | 0% | 245 | 1 | Town |
Florence is the largest city in Lauderdale County, with a population of 43,097.
Waterloo is the smallest city in Lauderdale County, with a population of 183.
There are 7 cities in Lauderdale County, Alabama.