11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Aliceville | 1 | 2,006 | 2,173 | -1.57% | 439 | 5 | City |
| Aliceville | 2 | 2,006 | 2,165 | -1.57% | 439 | 5 | City |
| Gordo | 3 | 1,541 | 1,632 | -1.15% | 474 | 3 | Town |
| Gordo | 4 | 1,541 | 1,628 | -1.15% | 474 | 3 | Town |
| Reform | 5 | 1,417 | 1,521 | -1.39% | 177 | 8 | Town |
| Reform | 6 | 1,417 | 1,517 | -1.39% | 177 | 8 | Town |
| Carrollton | 7 | 956 | 1,020 | -1.24% | 465 | 2 | Town |
| Carrollton | 8 | 956 | 1,016 | -1.24% | 465 | 2 | Town |
| Macedonia | 9 | 196 | 199 | -2.97% | 50 | 4 | CDP |
| Ethelsville | 10 | 47 | 51 | -2.08% | 83 | 1 | Town |
| Ethelsville | 11 | 47 | 51 | -2.08% | 83 | 1 | Town |
Aliceville is the largest city in Pickens County, with a population of 2,006.
Ethelsville is the smallest city in Pickens County, with a population of 47.
There are 11 cities in Pickens County, Alabama.