16 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Blytheville | 1 | 12,111 | 13,351 | -2.01% | 584 | 21 | City |
| Osceola | 2 | 6,380 | 6,959 | -1.79% | 557 | 11 | City |
| Manila | 3 | 3,747 | 3,691 | 0.29% | 968 | 4 | City |
| Gosnell | 4 | 2,637 | 2,897 | -1.93% | 1,633 | 2 | City |
| Leachville | 5 | 1,863 | 2,035 | -1.84% | 423 | 4 | City |
| Luxora | 6 | 847 | 934 | -2.08% | 995 | 1 | City |
| Wilson | 7 | 688 | 765 | -2.27% | 657 | 1 | City |
| Keiser | 8 | 684 | 752 | -2.01% | 1,795 | 0 | City |
| Joiner | 9 | 461 | 498 | -1.71% | 750 | 1 | City |
| Dyess | 10 | 310 | 338 | -1.9% | 323 | 1 | Town |
| Etowah | 11 | 237 | 250 | -1.25% | 40 | 6 | Town |
| Dell | 12 | 180 | 194 | -1.64% | 195 | 1 | Town |
| Burdette | 13 | 129 | 141 | -2.27% | 175 | 1 | Town |
| Bassett | 14 | 115 | 125 | -1.71% | 469 | 0 | Town |
| Marie | 15 | 95 | 105 | -2.06% | 646 | 0 | Town |
| Victoria | 16 | 17 | 19 | -5.56% | 54 | 0 | Town |
Blytheville is the largest city in Mississippi County, with a population of 12,111.
Victoria is the smallest city in Mississippi County, with a population of 17.
There are 16 cities in Mississippi County, Arkansas.