17 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Blytheville | 1 | 12,095 | 13,342 | -2.02% | 583 | 20.74 | City |
| Osceola | 2 | 6,372 | 6,966 | -1.83% | 677 | 9.42 | City |
| Manila | 3 | 3,733 | 3,685 | 0.27% | 964 | 3.87 | City |
| Gosnell | 4 | 2,623 | 2,897 | -2.05% | 1,624 | 1.61 | City |
| Leachville | 5 | 1,854 | 2,029 | -1.85% | 421 | 4.40 | City |
| Luxora | 6 | 847 | 934 | -1.97% | 995 | 0.85 | City |
| Keiser | 7 | 691 | 760 | -1.99% | 1,814 | 0.38 | City |
| Wilson | 8 | 687 | 766 | -2.28% | 656 | 1.05 | City |
| Armorel | 9 | 511 | 621 | 7.13% | 367 | 1.39 | CDP |
| Joiner | 10 | 458 | 495 | -1.5% | 745 | 0.61 | City |
| Dyess | 11 | 312 | 337 | -1.58% | 325 | 0.96 | Town |
| Etowah | 12 | 235 | 249 | -1.26% | 40 | 5.94 | Town |
| Dell | 13 | 177 | 194 | -1.67% | 192 | 0.92 | Town |
| Burdette | 14 | 129 | 141 | -1.53% | 175 | 0.74 | Town |
| Bassett | 15 | 113 | 123 | -1.74% | 461 | 0.24 | Town |
| Marie | 16 | 96 | 106 | -2.04% | 653 | 0.15 | Town |
| Victoria | 17 | 17 | 19 | 0% | 54 | 0.32 | Town |
Blytheville is the largest city in Mississippi County, with a population of 12,095.
Victoria is the smallest city in Mississippi County.
There are 17 cities in Mississippi County, Arkansas.