16 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Blytheville | 1 | 11,863 | 13,351 | -2.05% | 572 | 21 | City |
| Osceola | 2 | 6,264 | 6,959 | -1.82% | 547 | 11 | City |
| Manila | 3 | 3,758 | 3,691 | 0.29% | 971 | 4 | City |
| Gosnell | 4 | 2,585 | 2,897 | -1.97% | 1,601 | 2 | City |
| Leachville | 5 | 1,829 | 2,035 | -1.83% | 415 | 4 | City |
| Luxora | 6 | 830 | 934 | -2.01% | 975 | 1 | City |
| Wilson | 7 | 673 | 765 | -2.18% | 643 | 1 | City |
| Keiser | 8 | 671 | 752 | -1.9% | 1,761 | 0 | City |
| Joiner | 9 | 454 | 498 | -1.52% | 738 | 1 | City |
| Dyess | 10 | 305 | 338 | -1.61% | 317 | 1 | Town |
| Etowah | 11 | 235 | 250 | -0.84% | 40 | 6 | Town |
| Dell | 12 | 177 | 194 | -1.67% | 192 | 1 | Town |
| Burdette | 13 | 127 | 141 | -1.55% | 172 | 1 | Town |
| Bassett | 14 | 113 | 125 | -1.74% | 461 | 0 | Town |
| Marie | 15 | 93 | 105 | -2.11% | 633 | 0 | Town |
| Victoria | 16 | 17 | 19 | 0% | 54 | 0 | Town |
Blytheville is the largest city in Mississippi County, with a population of 11,863.
Victoria is the smallest city in Mississippi County, with a population of 17.
There are 16 cities in Mississippi County, Arkansas.