| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Blytheville | 1 | 11,986 | 13,350 | -1.97% | 578 | 21 | City |
| Osceola | 2 | 6,338 | 6,954 | -1.74% | 553 | 11 | City |
| Manila | 3 | 3,786 | 3,686 | 0.34% | 978 | 4 | City |
| Gosnell | 4 | 2,611 | 2,897 | -1.95% | 1,617 | 2 | City |
| Leachville | 5 | 1,850 | 2,035 | -1.75% | 420 | 4 | City |
| Luxora | 6 | 837 | 934 | -2.11% | 984 | 1 | City |
| Wilson | 7 | 687 | 765 | -2.14% | 656 | 1 | City |
| Keiser | 8 | 680 | 751 | -1.88% | 1,785 | 0 | City |
| Joiner | 9 | 457 | 498 | -1.72% | 743 | 1 | City |
| Dyess | 10 | 313 | 338 | -1.57% | 326 | 1 | Town |
| Etowah | 11 | 234 | 250 | -1.27% | 39 | 6 | Town |
| Dell | 12 | 178 | 194 | -1.66% | 193 | 1 | Town |
| Burdette | 13 | 137 | 148 | -1.44% | 186 | 1 | Town |
| Bassett | 14 | 113 | 125 | -1.74% | 461 | 0 | Town |
| Marie | 15 | 94 | 104 | -2.08% | 639 | 0 | Town |
| Victoria | 16 | 16 | 19 | -5.88% | 51 | 0 | Town |
Blytheville is the largest city in Mississippi County, with a population of 11,986.
Victoria is the smallest city in Mississippi County, with a population of 16.
There are 16 cities in Mississippi County, Arkansas.