| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Paragould | 1 | 31,406 | 29,658 | 0.87% | 988 | 32 | City |
| Marmaduke | 2 | 1,262 | 1,213 | 0.64% | 903 | 1 | City |
| Lafe | 3 | 418 | 420 | -0.24% | 206 | 2 | Town |
| O'Kean | 4 | 193 | 192 | 0% | 189 | 1 | Town |
| Delaplaine | 5 | 67 | 66 | 0% | 61 | 1 | Town |
Paragould is the largest city in Greene County, with a population of 31,406.
Delaplaine is the smallest city in Greene County, with a population of 67.
There are 5 cities in Greene County, Arkansas.