| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Des Arc | 1 | 1,828 | 1,899 | -0.71% | 870 | 2 | City |
| Hazen | 2 | 1,355 | 1,463 | -1.38% | 385 | 4 | City |
| De Valls Bluff | 3 | 484 | 518 | -1.22% | 443 | 1 | City |
| Fredonia (Biscoe) | 4 | 291 | 305 | -1.02% | 305 | 1 | Town |
| Ulm | 5 | 179 | 175 | 0.56% | 686 | 0 | Town |
Des Arc is the largest city in Prairie County, with a population of 1,828.
Ulm is the smallest city in Prairie County, with a population of 179.
There are 5 cities in Prairie County, Arkansas.