| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Forrest City | 1 | 12,158 | 12,977 | -1.22% | 601 | 20 | City |
| Hughes | 2 | 959 | 1,052 | -1.74% | 424 | 2 | City |
| Madison | 3 | 703 | 759 | -1.4% | 283 | 2 | City |
| Palestine | 4 | 469 | 505 | -1.47% | 138 | 3 | City |
| Caldwell | 5 | 413 | 444 | -1.43% | 130 | 3 | Town |
| Colt | 6 | 279 | 298 | -1.41% | 222 | 1 | City |
| Wheatley | 7 | 255 | 277 | -1.54% | 83 | 3 | City |
| Widener | 8 | 200 | 210 | -0.99% | 367 | 1 | Town |
Forrest City is the largest city in St. Francis County, with a population of 12,158.
Widener is the smallest city in St. Francis County, with a population of 200.
There are 8 cities in St. Francis County, Arkansas.