| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caruthersville | 1 | 5,126 | 5,539 | -1.63% | 994 | 5 | City |
| Hayti | 2 | 2,228 | 2,481 | -2.15% | 970 | 2 | City |
| Steele | 3 | 1,656 | 1,841 | -2.13% | 766 | 2 | City |
| Hayti Heights | 4 | 456 | 505 | -2.15% | 465 | 1 | City |
| Cooter | 5 | 313 | 344 | -1.88% | 1,061 | 0 | City |
| Wardell | 6 | 277 | 307 | -2.12% | 982 | 0 | Town |
| Holland | 7 | 177 | 194 | -2.21% | 1,060 | 0 | Town |
| Pascola | 8 | 80 | 88 | -2.44% | 500 | 0 | Village |
| Homestown | 9 | 65 | 73 | -2.99% | 528 | 0 | City |
| Bragg City | 10 | 61 | 69 | -3.17% | 299 | 0 | Town |
Caruthersville is the largest city in Pemiscot County, with a population of 5,126.
Bragg City is the smallest city in Pemiscot County, with a population of 61.
There are 10 cities in Pemiscot County, Missouri.