| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Sikeston | 1 | 15,930 | 16,265 | -0.33% | 889 | 18 | City |
| Scott City | 2 | 4,614 | 4,335 | 0.46% | 953 | 5 | City |
| Chaffee | 3 | 3,010 | 3,047 | -0.23% | 1,677 | 2 | City |
| Oran | 4 | 1,196 | 1,193 | 0.08% | 1,136 | 1 | City |
| Benton | 5 | 929 | 876 | 1.09% | 1,461 | 1 | City |
| Morley | 6 | 678 | 629 | 1.5% | 846 | 1 | City |
| Kelso | 7 | 550 | 557 | -0.18% | 1,735 | 0 | Village |
| Blodgett | 8 | 221 | 227 | -0.45% | 1,188 | 0 | City |
| Vanduser | 9 | 187 | 181 | 0.54% | 1,461 | 0 | Village |
| Commerce | 10 | 41 | 43 | -2.38% | 118 | 0 | Village |
Sikeston is the largest city in Scott County, with a population of 15,930.
Commerce is the smallest city in Scott County, with a population of 41.
There are 10 cities in Scott County, Missouri.