| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Macon | 1 | 5,546 | 5,446 | 0.25% | 915 | 6 | City |
| La Plata | 2 | 1,249 | 1,250 | -0.16% | 787 | 2 | City |
| Bevier | 3 | 623 | 633 | -0.32% | 600 | 1 | City |
| Atlanta | 4 | 368 | 376 | -0.54% | 1,076 | 0 | City |
| Callao | 5 | 244 | 250 | -0.41% | 472 | 1 | City |
| New Cambria | 6 | 149 | 153 | -0.67% | 222 | 1 | City |
| Elmer | 7 | 50 | 52 | -1.96% | 198 | 0 | City |
| Ethel | 8 | 47 | 47 | 0% | 203 | 0 | Town |
Macon is the largest city in Macon County, with a population of 5,546.
Ethel is the smallest city in Macon County, with a population of 47.
There are 8 cities in Macon County, Missouri.