| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fredericktown | 1 | 4,621 | 4,433 | 0.81% | 1,068 | 4 | City |
| Junction City | 2 | 287 | 285 | 0% | 802 | 0 | Village |
| Cobalt | 3 | 264 | 262 | 0% | 1,772 | 0 | Village |
| Marquand | 4 | 190 | 188 | 0% | 798 | 0 | City |
Fredericktown is the largest city in Madison County, with a population of 4,621.
Marquand is the smallest city in Madison County, with a population of 190.
There are 4 cities in Madison County, Missouri.