| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Perryville | 1 | 8,595 | 8,554 | 0.02% | 1,053 | 8 | City |
| Frohna | 2 | 242 | 244 | 0% | 268 | 1 | City |
Perryville is the largest city in Perry County, with a population of 8,595.
Frohna is the smallest city in Perry County, with a population of 242.
There are 2 cities in Perry County, Missouri.