| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Mound City | 1 | 1,001 | 994 | 0.2% | 803 | 1 | City |
| Oregon | 2 | 829 | 824 | 0.24% | 893 | 1 | City |
| Maitland | 3 | 276 | 274 | 0% | 885 | 0 | City |
| Forest City | 4 | 245 | 245 | 0% | 250 | 1 | City |
| Craig | 5 | 103 | 103 | 0% | 396 | 0 | City |
Mound City is the largest city in Holt County, with a population of 1,001.
Craig is the smallest city in Holt County, with a population of 103.
There are 5 cities in Holt County, Missouri.