Caruthersville
- County:
- Pemiscot County
- County Seat:
- Yes
- Area (mi²):
- 5.158
- State:
- Missouri
Caruthersville is a city located in Pemiscot County, Missouri. Caruthersville has a 2026 population of 5,170. It is also the county seat of Pemiscot County. Caruthersville is currently declining at a rate of -1.49% annually and its population has decreased by -6.68% since the most recent census, which recorded a population of 5,540 in 2020.