Blytheville
- County:
- Mississippi County
- County Seat:
- Yes
- Area (mi²):
- 20.738
- State:
- Arkansas
Blytheville is a city located in Mississippi County, Arkansas. Blytheville has a 2026 population of 12,359. It is also the county seat of Mississippi County. Blytheville is currently declining at a rate of -1.92% annually and its population has decreased by -7.43% since the most recent census, which recorded a population of 13,351 in 2020.