5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Des Arc | 1 | 1,827 | 1,897 | -0.76% | 869 | 2 | City |
| Hazen | 2 | 1,366 | 1,473 | -1.59% | 388 | 4 | City |
| De Valls Bluff | 3 | 488 | 520 | -1.41% | 447 | 1 | City |
| Fredonia (Biscoe) | 4 | 291 | 306 | -1.02% | 305 | 1 | Town |
| Ulm | 5 | 179 | 174 | 0.56% | 686 | 0 | Town |
Des Arc is the largest city in Prairie County, with a population of 1,827.
Ulm is the smallest city in Prairie County, with a population of 179.
There are 5 cities in Prairie County, Arkansas.