5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grand Junction | 1 | 71,752 | 65,759 | 1.7% | 1,760 | 41 | City |
| Fruita | 2 | 14,034 | 13,424 | 0.88% | 1,752 | 8 | City |
| Palisade | 3 | 2,609 | 2,562 | 0.35% | 2,196 | 1 | Town |
| De Beque | 4 | 474 | 491 | -0.84% | 171 | 3 | Town |
| Collbran | 5 | 363 | 371 | -0.55% | 651 | 1 | Town |
Grand Junction is the largest city in Mesa County, with a population of 71,752.
Collbran is the smallest city in Mesa County, with a population of 363.
There are 5 cities in Mesa County, Colorado.