5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grand Junction | 1 | 72,951 | 65,759 | 1.67% | 1,789 | 41 | City |
| Fruita | 2 | 14,156 | 13,424 | 0.87% | 1,768 | 8 | City |
| Palisade | 3 | 2,619 | 2,562 | 0.38% | 2,205 | 1 | Town |
| De Beque | 4 | 471 | 491 | -0.63% | 170 | 3 | Town |
| Collbran | 5 | 362 | 371 | -0.28% | 649 | 1 | Town |
Grand Junction is the largest city in Mesa County, with a population of 72,951.
Collbran is the smallest city in Mesa County, with a population of 362.
There are 5 cities in Mesa County, Colorado.