| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Grand Junction | 1 | 73,036 | 65,752 | 1.68% | 1,791 | 41 | City |
| Fruita | 2 | 14,128 | 13,430 | 0.89% | 1,764 | 8 | City |
| Palisade | 3 | 2,609 | 2,562 | 0.38% | 2,196 | 1 | Town |
| De Beque | 4 | 473 | 489 | -0.63% | 170 | 3 | Town |
| Collbran | 5 | 353 | 364 | -0.56% | 633 | 1 | Town |
Grand Junction is the largest city in Mesa County, with a population of 73,036.
Collbran is the smallest city in Mesa County, with a population of 353.
There are 5 cities in Mesa County, Colorado.