7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Palatka | 1 | 10,899 | 10,476 | 0.79% | 1,106 | 9.85 | City |
| Flagler Estates | 2 | 3,706 | 3,348 | 0.87% | 313 | 11.84 | CDP |
| Crescent City | 3 | 1,720 | 1,659 | 0.7% | 833 | 2.06 | City |
| Interlachen | 4 | 1,518 | 1,428 | 1.2% | 249 | 6.09 | Town |
| East Palatka | 5 | 1,418 | 1,625 | -1.12% | 446 | 3.18 | CDP |
| Pomona Park | 6 | 832 | 782 | 1.22% | 273 | 3.04 | Town |
| Welaka | 7 | 759 | 719 | 1.07% | 511 | 1.48 | Town |
Palatka is the largest city in Putnam County, with a population of 10,899.
Welaka is the smallest city in Putnam County.
There are 7 cities in Putnam County, Florida.