| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Palatka | 1 | 10,966 | 10,449 | 0.86% | 1,094 | 10 | City |
| Crescent City | 2 | 1,744 | 1,656 | 0.93% | 845 | 2 | City |
| Interlachen | 3 | 1,521 | 1,410 | 1.26% | 250 | 6 | Town |
| Pomona Park | 4 | 834 | 779 | 1.21% | 274 | 3 | Town |
| Welaka | 5 | 796 | 725 | 1.27% | 536 | 1 | Town |
Palatka is the largest city in Putnam County, with a population of 10,966.
Welaka is the smallest city in Putnam County, with a population of 796.
There are 5 cities in Putnam County, Florida.